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Literature summary extracted from

  • Yang, L.; Ma, L.; Lai, D.
    Over-expression of fibroblast activation protein alpha increases tumor growth in xenografts of ovarian cancer cells (2013), Acta Biochim. Biophys. Sin. (Shanghai), 45, 928-937.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B28 recombinant expression in Escherichia coli TOP10 cells and transfection of SKOV-3 and HO-8910 cells, two poorly differentiated ovarian serous adenocarcinoma cell lines, using a lentivirus expression vector, quantitative real-time PCR enzyme expression analzsis Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.B28 cell surface
-
 Homo sapiens 9986
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B28 Homo sapiens Q12844
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B28 additional information the enzyme is widely expressed in tumor microenvironment. No enzyme expression in wild-type SKOV-3 and HO-8910 cells, two poorly differentiated ovarian serous adenocarcinoma cell lines Homo sapiens
-
3.4.21.B28 ovary cancer cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B28 FAPalpha
-
 Homo sapiens
3.4.21.B28 fibroblast activation protein alpha
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.B28 evolution the enzyme belongs to the post-prolyl peptidase family Homo sapiens
3.4.21.B28 physiological function the enzyme promotes ovarian cancer cell proliferation, drug resistance, invasiveness, and migration in vitro and it significantly facilitates tumor growth in xenograft tumor tissues. The enzyme might directly promote tumor growth and invasiveness in ovarian cancer cells Homo sapiens